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Scientific Articles:
Hongwei Cheng, Wei Jiang, Frank M. Phillips, Rex C. Haydon, Ying Peng, Lan Zhou, Hue H. Luu, Naili An, Benjamin Breyer, Pantila Vanichakarn, Jan Paul Szatkowski, Jae Yoon Park, and Tong-Chuan He
Osteogenic Activity of the Fourteen Types of Human Bone Morphogenetic Proteins (BMPs)
J Bone Joint Surg Am 2003; 85: 1544-1552 [Abstract] [Full text] [PDF]
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Electronic letters published:

[Read Letter to the Editor] Dr He, et al, respond to Dr Trieb
Tong-Chuan He, M.D., Ph.D., H. Cheng, M.D.,Ph.D., W.Jiang, BA, F. M. Phillips, M.D., R. C. Haydon, M.D., Ph.D., Y. Peng, M.D., L. Zhou, M.D., Ph.D., H.H.Luu, M.D., N. An, M.D., B. Breyer, M.D., P. Vanichakarn, BS, J. P. Szatkowski, BS, J. Y. Park, BS.   (24 November 2003)
[Read Letter to the Editor] Osteogenic Activity of Human BMP's
Klemens Trieb   (24 November 2003)

Dr He, et al, respond to Dr Trieb 24 November 2003
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Tong-Chuan He, M.D., Ph.D.,
Physician
University of Chicago Medical Center, Chicago, IL,
H. Cheng, M.D.,Ph.D., W.Jiang, BA, F. M. Phillips, M.D., R. C. Haydon, M.D., Ph.D., Y. Peng, M.D., L. Zhou, M.D., Ph.D., H.H.Luu, M.D., N. An, M.D., B. Breyer, M.D., P. Vanichakarn, BS, J. P. Szatkowski, BS, J. Y. Park, BS.

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Re: Dr He, et al, respond to Dr Trieb

tche{at}surgery.bsd.uchicago.edu Tong-Chuan He, M.D., Ph.D., et al.

We thank Dr. Trieb for identifying this error. The correct statement should read “However, all BMPs except BMP-3 and 12 were shown to induce alkaline phosphatase activity in TE-85 cells”. In several independent experiments, we found that the TE-85 cells exhibited a base line alkaline phosphatase activity, and the BMP-mediated induction of alkaline phosphatase activity was at least one order of magnitude lower than that in C2C12 and C3H10T1/2 cells.

In further reviewing our paper, we found an additional error in Fig. 2 (p.1547). According to our data, BMP-2, 4, 6, 7, and 9 were shown to induce the osteogenic differentiation of C2C12 cells. In the publication, BMP-6 was accidentally omitted.

Hongwei Cheng, MD, PhD Wei Jiang, BA Frank M. Phillips, MD Rex C. Haydon, MD, PhD Ying Peng MD Lan Zhou, MD, PhD Hue H. Luu, MD Naili An, MD Benjamin Breyer, MD Pantila Vanichakarn, BS Jan Paul Szatkowski, BS Jae Yoon Park, BS Tong-Chuan He, MD, PhD.
Osteogenic Activity of Human BMP's 24 November 2003
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Klemens Trieb

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Re: Osteogenic Activity of Human BMP's

Klemens.Trieb{at}akh-wien.ac.at Klemens Trieb

TO THE EDITOR:

The paper, "Osteogenic activity of the fourteen types of human bone morphogenetic proteins", by Cheng et al. provides important information about the osteogenic potential of different BMPs.

On page 1548 (Line 9 from the bottom, left column) the authors write that BMP 3 and 10 do not stimulate alkaline phosphatase activity in TE-85 cells, but in Figure 1C, this seems to be true for BMP-3 and 12. Could the authors clarify this detail of their excellent paper?

Klemens Trieb, M.D.: Department of Orthopaedic Surgery, University of Vienna, 1090 Vienna, Austria

Univ.Prof. Dr. Klemens Trieb Department of Orthopedics University Vienna Währingergürtel 18-20 A-1090 Vienna, Austria Tel.: +43-1-40400-4070 FAX: +43-1-40400-4077 E-mail: Klemens.Trieb@akh-wien.ac.at