The Journal of Bone and Joint Surgery (American). 2009;91:23-31.
doi:10.2106/JBJS.I.00518
© 2009 The Journal of Bone and Joint Surgery, Inc.
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Locally Delivered Bisphosphonate for Enhancement of Bone Formation and Implant Fixation

J. Dennis Bobyn, PhD1, Kimberly McKenzie, BSc2, Dorota Karabasz, BSc2, Jan J. Krygier, CET2 and Michael Tanzer, MD2

1 Montreal General Hospital, 1650 Cedar Avenue, Room LS1-409, Montreal, QC H3G 1A4, Canada. E-mail address for J.D. Bobyn: john.bobyn@mcgill.ca
2 Jo Miller Orthopaedic Research Laboratory, 1650 Cedar Avenue, Room LS1-409, Montreal, QC H3G 1A4, Canada

The first 150 words of the full text of this article appear below.


   Introduction
 
Bone growth into porous materials has proven to be a very effective method for attaching prosthetic implants to the osseous skeleton1-3. However, there remains a need to develop modalities that can accelerate and/or increase biologic fixation. The more rapidly that bone forms and the greater the amount of bone that forms about and/or within an implant, the faster the implant becomes mechanically secured against the disruptive forces of load bearing and the sooner patients can safely return to their activities of daily living. In situations in which the condition of the bone stock or the healing process is compromised (e.g., when the patient is elderly or has osteoporosis) or the initial stability of the implant is more tenuous or crucial (e.g., during posttraumatic, revision, or minimally invasive procedures), the construct would clearly benefit from enhanced mechanical support.

Bisphosphonates reduce bone catabolism by interfering with cell metabolism and causing osteoclast . . . [Full Text of this Article]


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