The Journal of Bone and Joint Surgery (American). 2009;91:67-73.
doi:10.2106/JBJS.I.00447
© 2009 The Journal of Bone and Joint Surgery, Inc.
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In Vivo Analysis of Polyethylene Wear Particles After Total Knee Arthroplasty: The Influence of Improved Materials and Designs

Yukihide Minoda, MD, PhD1, Akio Kobayashi, MD, PhD1, Hiroyoshi Iwaki, MD, PhD1, Kentarou Iwakiri, MD, PhD1, Fumiaki Inori, MD, PhD1, Ryo Sugama, MD, PhD1, Mitsuhiko Ikebuchi, MD1, Yoshinori Kadoya, MD, PhD1 and Kunio Takaoka, MD, PhD1

1 Department of Orthopaedic Surgery, Osaka City University Graduate School of Medicine, 1-4-3 Asahi-machi Abeno-ku, Osaka 545-8585, Japan. E-mail address for Y. Minoda: yminoda@msic.med.osaka-cu.ac.jp

The first 150 words of the full text of this article appear below.


   Introduction
 
Polyethylene wear particles induce macrophages to release cytokines, which can lead to osteolysis and aseptic loosening of total joint prostheses1. The generation of polyethylene wear particles is one of the most important factors that affects the midterm and long-term clinical results associated with total knee arthroplasty2,3. The generation of polyethylene wear particles is correlated with the activity level of the patient4, and greater demands are placed on a total knee prosthesis when it is implanted in a younger, more active patient5. Therefore, to achieve better long-term results for patients who have higher activity levels, modifications of materials (i.e., highly cross-linked polyethylene and alumina ceramic) and design (i.e., mobile bearing and medial pivot) have been developed to reduce polyethylene wear after total knee arthroplasty.

It takes decades to evaluate the long-term results of newly introduced total knee prostheses. Thus, it is particularly important to examine in vivo . . . [Full Text of this Article]


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