The Journal of Bone and Joint Surgery (American). 2008;90:202-208.
doi:10.2106/JBJS.H.00672
© 2008 The Journal of Bone and Joint Surgery, Inc.
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Metal Ion Measurement as a Diagnostic Tool to Identify Problems with Metal-on-Metal Hip Resurfacing

K. De Smet, MD1, R. De Haan, MD2, A. Calistri, MD1, P.A. Campbell, PhD3, E. Ebramzadeh, PhD3, C. Pattyn, MD4 and H.S. Gill, DPhil5

1 ANCA Medical Centre, Krijgslaan 181, 9000 Ghent, Belgium
2 University Hospital Brussels, Laarbeeklaan 101, 1090 Brussels, Belgium
3 J. Vernon Luck Sr., MD Orthopaedic Hospital Research Center, 2400 South Flower Street, Los Angeles, CA 90007
4 University Clinic, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium
5 Botnar Research Centre, Nuffield Orthopaedic Centre, Oxford OX3 7LD, United Kingdom

The first 150 words of the full text of this article appear below.


   Introduction
 
Metal-on-metal bearings for hip replacement are gaining popularity as an alternative to the most widely used bearing couple of metal on polyethylene1. The recent resurgence of hip resurfacing with the so-called third and fourth generations of hip resurfacing arthroplasty devices has played a substantial role in the wider use of metal-on-metal bearings2-4. Concerns about the wear of polyethylene and the role of polyethylene wear debris in the process of aseptic loosening have also increased the use of hard-on-hard bearing couples.

However, wear still takes place with metal-on-metal bearings, and there is concern about the relatively high levels of metallic ions released into the body as a consequence. Cobalt-chromium alloy is the metal used for metal-on-metal implants and, while these elements are required for normal biological function, high concentrations of cobalt and chromium are toxic and are known to interfere with a number of biological processes5,6. The metal . . . [Full Text of this Article]


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