The Journal of Bone and Joint Surgery (American). 2007;89:163-166.
doi:10.2106/JBJS.F.01513
© 2007 The Journal of Bone and Joint Surgery, Inc.
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Early Onset Scoliosis: Future Directions

George H. Thompson, MD, Lawrence G. Lenke, MD, Behrooz A. Akbarnia, MD, Richard E. McCarthy, MD and Robert M. Campbell, Jr., MD

Corresponding author:
George H. Thompson, MD
Division of Pediatric Orthopaedics, Rainbow Babies and Children's Hospital, University Hospitals of Cleveland, Case Western Reserve University, 11100 Euclid Avenue, Cleveland, OH 44106.
E-mail address for G.H. Thompson: ght@po.cwru.edu

The first 150 words of the full text of this article appear below.


   Introduction
 
The management of children with severe, progressive early onset scoliosis has been greatly advanced in the last decade, yet there is considerably more research to be accomplished in the future. In this concluding article, we review some of the major issues for future research with regard to this rare but potentially fatal disease.


   Etiological Considerations
 
Despite the similar clinical appearances of the various forms of early onset scoliosis, the etiologies are different; however, little is known regarding etiology, particularly with regard to genetic defects. Further research is necessary to distinguish the various types of early onset scoliosis. Only by understanding the etiology can true advances be made in altering the natural history of early onset scoliosis. Research in the area of etiology will require increased funding through the National Institutes of Health and other agencies. Due to its low prevalence, early onset scoliosis currently does not have a high priority with these . . . [Full Text of this Article]


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