The Journal of Bone and Joint Surgery (American). 2007;89:123-142.
doi:10.2106/JBJS.F.00836
© 2007 The Journal of Bone and Joint Surgery, Inc.
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The Immature Spine in Type-1 Neurofibromatosis

Alvin H. Crawford, MD, Shital Parikh, MD, Elizabeth K. Schorry, MD and Diane Von Stein, MD

Corresponding author:
Alvin H. Crawford, MD
Spine Center and Division of Pediatric Orthopaedic Surgery, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, ML 2017, Cincinnati, OH 45229.
E-mail address: alvin.crawford@cchmc.org

The first 150 words of the full text of this article appear below.


   Introduction
 
Neurofibromatosis is a multisystem disease that primarily affects cell growth of neural tissue. The intent of this article is to identify the spinal complications in skeletally immature patients that are most commonly associated with neurofibromatosis and to present strategies for management.


   Historical Review
 
The neurofibromatoses are a spectrum of multifaceted diseases involving not only neuroectoderm and mesoderm but also endoderm. These disorders present with a wide range of clinical manifestations that have in common the presence of schwannomas, neurofibromas, and/or café au lait spots. Clinically, this multisystemic, hereditary disease may manifest as abnormalities of the skin, nervous tissue, bones, and soft tissues. The primary pathology is believed to be a tumor-suppressor disorder. Previous reports have dealt primarily with specific entities, such as spinal deformity, paraplegia, hemihypertrophy with overgrowth phenomena of the extremities, soft-tissue tumors, neoplasia, and congenital tibial dysplasia and pseudarthrosis following extremity fractures. Scoliosis is the most common musculoskeletal complication of . . . [Full Text of this Article]


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