The Journal of Bone and Joint Surgery (American). 2007;89:871-882.
doi:10.2106/JBJS.E.01070
© 2007 The Journal of Bone and Joint Surgery, Inc.
Antibiotic-Impregnated Cement Spacers for the Treatment of Infection Associated with Total Hip or Knee Arthroplasty
Quanjun Cui, MD, MS1,
William M. Mihalko, MD, PhD1,
John S. Shields, MD1,
Michael Ries, MD2 and
Khaled J. Saleh, MD, MSc, FRCS(C)3
1 Department of Orthopaedic Surgery, University of Virginia, Box 800159,
Charlottesville, VA 22908
2 Department of Orthopaedic Surgery, University of California San Francisco
Medical Center, 500 Parnassus Avenue, San Francisco, CA 94143
3 Department of Orthopaedic Surgery and Health Evaluative Sciences, University
of Virginia, 400 Ray C. Hunt Drive, Charlottesville, VA, 22903. E-mail
address:
Saleh@Virginia.edu
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Introduction
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Infection at the site
of a total joint arthroplasty can be classified into four basic categories:
Type I (early postoperative), Type II (late chronic), Type III (acute
hematogenous), and Type IV (positive intraoperative cultures with clinically
unapparent infection).
The current standard
of care for late chronic infection is considered to be two-stage revision
arthroplasty including removal of the prosthesis and cement, thorough
débridement, placement of an antibiotic-impregnated cement spacer, a
course of intravenous antibiotics, and a delayed second-stage revision
arthroplasty.
The choice of the
spacer, either articulating or nonarticulating, is based on many factors,
including the amount of bone loss, the condition of the soft tissues, the need
for joint motion, the availability of prefabricated spacers or molding
methods, and antibiotic selection.
Current data have
demonstrated that the use of antibiotic-impregnated cement spacers has
improved the outcomes of the treatment of infection associated with total
joint arthroplasty.
. . . [Full Text of this Article]

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