The Journal of Bone and Joint Surgery (American). 2007;89:871-882.
doi:10.2106/JBJS.E.01070
© 2007 The Journal of Bone and Joint Surgery, Inc.
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Current Concepts Review

Antibiotic-Impregnated Cement Spacers for the Treatment of Infection Associated with Total Hip or Knee Arthroplasty

Quanjun Cui, MD, MS1, William M. Mihalko, MD, PhD1, John S. Shields, MD1, Michael Ries, MD2 and Khaled J. Saleh, MD, MSc, FRCS(C)3

1 Department of Orthopaedic Surgery, University of Virginia, Box 800159, Charlottesville, VA 22908
2 Department of Orthopaedic Surgery, University of California San Francisco Medical Center, 500 Parnassus Avenue, San Francisco, CA 94143
3 Department of Orthopaedic Surgery and Health Evaluative Sciences, University of Virginia, 400 Ray C. Hunt Drive, Charlottesville, VA, 22903. E-mail address: Saleh@Virginia.edu

The first 150 words of the full text of this article appear below.


    Introduction
 
Formula Infection at the site of a total joint arthroplasty can be classified into four basic categories: Type I (early postoperative), Type II (late chronic), Type III (acute hematogenous), and Type IV (positive intraoperative cultures with clinically unapparent infection).

Formula The current standard of care for late chronic infection is considered to be two-stage revision arthroplasty including removal of the prosthesis and cement, thorough débridement, placement of an antibiotic-impregnated cement spacer, a course of intravenous antibiotics, and a delayed second-stage revision arthroplasty.

Formula The choice of the spacer, either articulating or nonarticulating, is based on many factors, including the amount of bone loss, the condition of the soft tissues, the need for joint motion, the availability of prefabricated spacers or molding methods, and antibiotic selection.

Formula Current data have demonstrated that the use of antibiotic-impregnated cement spacers has improved the outcomes of the treatment of infection associated with total joint arthroplasty.

. . . [Full Text of this Article]


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