The Journal of Bone and Joint Surgery (American). 2007;89:668-671.
doi:10.2106/JBJS.F.01609
© 2007 The Journal of Bone and Joint Surgery, Inc.
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Developmental Biology in Orthopaedics

Summary of the 2006 AAOS Research Symposium*

Benjamin A. Alman, MD1 and William A. Horton, MD2

1 Division of Orthopaedic Surgery and Program in Developmental Biology, The Hospital for Sick Children, 555 University Avenue, Toronto, ON M5G 1X8, Canada
2 Oregon Health and Science University, Shriners Hospital for Children, 3101 S.W. Sam Jackson Park Road, Portland, OR 97239

The first 150 words of the full text of this article appear below.


   Introduction
 
During normal fetal development, a variety of cell-signaling pathways are regulated in a coordinated manner so that cells can proliferate, move, and even die off in an organized fashion that allows organs to develop. Over the past decade, there have been tremendous advances in understanding how the musculoskeletal system develops. Knowledge about these pathways and how they regulate cell behavior can be applied to musculoskeletal pathologic conditions and repair processes. Many of the pathways that are important in development can be targeted therapeutically; interestingly, many such agents have been identified by their teratologic potential. Identifying the role of these key signaling pathways in musculoskeletal disorders carries strong potential to rapidly identify new therapeutic approaches. Genetically modified organisms, such as transgenic mice, are important tools in this work. Because these organisms have genetic abnormalities from the start of development, they can be used to study the role of genes or cell-signaling . . . [Full Text of this Article]


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