The Journal of Bone and Joint Surgery (American). 2006;88:148-155.
doi:10.2106/JBJS.F.00586
© 2006 The Journal of Bone and Joint Surgery, Inc.
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The Influence of Antibiotics on the Fatigue Life of Acrylic Bone Cement

Paul D. Postak, BSc and A. Seth Greenwald, DPhil(Oxon)

Corresponding author:
A. Seth Greenwald, DPhil(Oxon)
Orthopaedic Research Laboratories, Lutheran Hospital, a Cleveland
Clinic hospital, 1730 West 25th Street, Cleveland, OH 44113. E-mail address:
seth@orl-inc.com

The first 150 words of the full text of this article appear below.


   Introduction
 
Aseptic loosening attributed to cement fracture and subsequent disruption of fixation interfaces remains a major long-term mode of failure of arthroplasties performed with cement1 (Fig. 1). The fracture strength of bone cement, especially in fatigue, is an important indicator of cement integrity and the potential for fixation failure.


Figure Removed (Available Only in the Full Text)
 Fig. 1: A failed cemented total hip replacement showing marked radiolucency indicating disruption of the bone-cement interface. (Reprinted, with permission, from: Greenwald AS. Biomechanical considerations in revision arthroplasty. In: Welch RD, editor. Hip: proceedings of the Hip Society. St Louis: CV Mosby; 1984. p 254-70.)

 
In current practice, orthopaedic surgeons may choose to utilize antibiotics in bone cement for prophylaxis or treatment of a known infection. However, the antibiotics, bone cement, and mixing method employed lead to variability in the quality of the end product2-5.

To date, several United States orthopaedic manufacturers have received Food and Drug Administration (FDA) 510(k) clearance . . . [Full Text of this Article]


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