The Journal of Bone and Joint Surgery (American). 2006;88:10-14.
doi:10.2106/JBJS.F.00897
© 2006 The Journal of Bone and Joint Surgery, Inc.
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Letters to the Editor: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when Letters to the Editor are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrowReprints and Permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Winet, H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Winet, H.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Technorati  
What's this?

Transport in Haroldfrostland: A Metaphor for Fluid Movement to and through Basic Multicellular Units

Howard Winet, PhD

Corresponding author:
Howard Winet, PhD
Orthopaedic Hospital University of California at Los Angeles, 2400 South Flower Street, Los Angeles, California 90007.
E-mail address: hwinet@ucla.edu

The first 150 words of the full text of this article appear below.

In 1963, Harold Frost published his basic multicellular unit (BMU) model in which osteoblasts and osteoclasts were viewed as partners in remodeling, linked both in time and space1. The model has become known as the "Utah paradigm."2 According to the paradigm, bone cells are coordinated within osteons at the anatomical BMU site. The traditional mechanism linking mechanical stress with BMU activities is the so-called "Wolff's Law."3 Although not fitting scientific guidelines which define a true law4, this purely solid mechanical concept is still accepted as valid by some members of the orthopaedic community5. The questions (1) How do the messages by which bone cells communicate travel; and (2) How is mechanical stress transmitted? were not answered by "Wolff's Law." Question 1 was left to diffusion6. Question 2 was answered by non-specific piezoelectric models7. In 1970, Anderson and Eriksson7 pushed the first pin nail into the . . . [Full Text of this Article]


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Technorati Technorati    What's this?