The Journal of Bone and Joint Surgery (American). 2006;88:110-114.
doi:10.2106/JBJS.F.00030
© 2006 The Journal of Bone and Joint Surgery, Inc.
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Letters to the Editor: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when Letters to the Editor are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrowReprints and Permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Andersson, G. B.J.
Right arrow Articles by Setton, L. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Andersson, G. B.J.
Right arrow Articles by Setton, L. A.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Technorati  
What's this?

Directions for Future Research

Gunnar B.J. Andersson, MD, PhD, Howard S. An, MD, Theodore R. Oegema, Jr., PhD and Lori A. Setton, PhD

Corresponding author:
Gunnar B.J. Andersson, MD, PhD
Department of Orthopedic Surgery, Rush University Medical Center, 1653 West Congress Parkway, 1471 Jelke, Chicago, IL 60612.
E-mail address: gunnar_andersson@rsh.net

The first 150 words of the full text of this article appear below.


   Introduction
 
During the workshop, five subgroups met to identify research opportunities. The following outlines summarize their work and conclusions on knowledge gaps and research agendas. Because these topics are closely related, duplication is unavoidable yet underscores key areas.


   Research into the Biology of the Intervertebral Disc and Disc Degeneration
 
Aging and Degeneration

  • Role of gender
  • Role of ethnicity
  • Link between gene mutation and mechanisms of degeneration

Study of Disc

  • Should not study in isolation; functions as whole spinal segment
  • Difficult to study disc in isolation; organ or cell culture results must be related to disc in vivo
  • Need for immortalized disc cell lines
  • Need for use of transgenic and knockout mouse models to study molecular function
  • Need to study interactions of different cell types
  • Need for intact human organ culture model (heparinized donor discs) under load

Disc-Cell Phenotypes

  • Need for cell markers to distinguish which cells are from the anulus pulposus, which are from the nucleus pulposus, and which are from the end plate
  • Need for markers to distinguish disc . . . [Full Text of this Article]


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Technorati Technorati    What's this?