The Journal of Bone and Joint Surgery (American). 2005;87:1113-1119.
doi:10.2106/JBJS.D.02436
© 2005 The Journal of Bone and Joint Surgery, Inc.
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Viscosupplementation Pseudotumor

A Case Report

Kevin B. Jones, MD1, Pranav P. Patel, MD1, Barry R. DeYoung, MD1 and Joseph A. Buckwalter, MD, MS1

1 Departments of Orthopaedic Surgery and Rehabilitation (K.B.J. and J.A.B.), Musculoskeletal Radiology (P.P.P.), and Surgical Pathology (B.R.DeY.), University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, IA 52242. E-mail address for K.B. Jones: kevin-jones@uiowa.edu

Investigation performed at the Departments of Orthopaedic Surgery and Rehabilitation, Musculoskeletal Radiology, and Surgical Pathology, University of Iowa Hospitals and Clinics, Iowa City, Iowa

The first 150 words of the full text of this article appear below.


   Introduction
 
Use of intra-articular viscosupplementation has increased dramatically in recent years. Associated complications have been reported1-10. Complications associated specifically with Hylan G-F 20, commercially available as Synvisc (Wyeth-Ayerst Pharmaceuticals, Philadelphia, Pennsylvania), have included both transient and, rarely, prolonged inflammatory reactions3,10. We report an unusual complication of intra-articular injection of Hylan G-F 20: the formation of a soft-tissue mass that was initially diagnosed as a sarcoma by expert pathologists. The patient consented to the publication of the details of the case and helped confirm their accuracy.


   Case Report
 
Histopathologic slides of tissue obtained with an excisional biopsy of a soft-tissue mass were sent to the musculoskeletal pathologist at our institution from a community hospital. The accompanying clinical history documented an expanding painful mass, of two months' duration, in the posterolateral aspect of the left knee of a thirty-six-year-old woman with adult-onset diabetes and hypertension. The accompanying report on the magnetic resonance imaging . . . [Full Text of this Article]


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Another Diagnosis
Nicholas A. DiNubile, M.D.
JBJS Online, 1 Aug 2005 [Full text]