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The Journal of Bone and Joint Surgery (American). 2004;86:98-104
© 2004 The Journal of Bone and Joint Surgery, Inc.

Fluorodeoxyglucose Positron Emission Tomography Scanning: Basic Principles and Imaging of Adult Soft-Tissue Sarcomas

Ernest U. Conrad, III, MD, Hannah D. Morgan, MD, Cheryl Vernon, BSMT, Scott M. Schuetze, MD and Janet F. Eary, MD

Corresponding author:
Ernest U. Conrad III, MD
Department of Orthopaedics and Sports Medicine, University of
Washington, Box 356500, Seattle, WA 98195-6500. E-mail address:
chappiec@u.washington.edu

The first 150 words of the full text of this article appear below.


   Basic Principles of Positron Emission Tomography Scanning
 
Positron emission tomography (PET) has become a powerful tool to evaluate various biological processes involving the musculoskeletal system. The positron-emitting radioisotopes commonly used in positron emission tomography in clinical practice (F-18, C-11, and O-15) can be incorporated into a number of physiologic tracers and substrates, with the synthesis of these radiopharmaceuticals taking place in association with a radioisotope-producing cyclotron. The ability of radiopharmaceuticals to function as indicators of specific physiologic processes provides an important measure of an aspect of a disease or repair that might not be apparent on the basis of structural changes alone. The use of positron emission tomography imaging and specific radiopharmaceuticals to measure biological activity of tissue quantitatively and to relate it to structure is unique in the diagnostic imaging process.

Radioactive decay involves the emission of a positron (a positive electron) from a proton excess in a radioactive nucleus. The positron travels only a few . . . [Full Text of this Article]


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