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The Journal of Bone and Joint Surgery (American). 2004;86:2567
© 2004 The Journal of Bone and Joint Surgery, Inc.

Letter to the Editor

Therapeutic Effects of Hyaluronic Acid on Osteoarthritis of the Knee

Joseph Bernstein, MD1

1 Veterans' Hospital
424 Stemmler Hall
Philadelphia, PA 19104-6081
orthodoc@post.harvard.edu

The first 20% of the full text of this article appears below.

To The Editor:

The conclusions reached in the study, "Therapeutic Effects of Hyaluronic Acid on Osteoarthritis of the Knee. A Meta-Analysis of Randomized Controlled Trials" (2004;86:538-45), by Wang et al.—namely, that "the therapeutic efficacy and safety of intra-articular injection of hyaluronic acid for the treatment of osteoarthritis of the knee" was confirmed—seems to be in conflict with a paper that appeared in JAMA just a few months ago1. In that meta-analysis, the authors concluded: "Intra-articular hyaluronic acid has a small effect when compared with an intra-articular placebo. The presence of publication bias suggests even this effect may be overestimated."

Can the authors please comment on this apparent discrepancy? Also, can the . . . [Full Text of this Article]

Sheng-Mou Hou, MD, PhD, MPH and Chen-Ti Wang, MD

Corresponding author:
Sheng-Mou Hou, MD, PhD, MPH
Department of Orthopedics
National Taiwan University Hospital and
National Taiwan University
College of Medicine
No. 7, Chung-Shan South Road
Taipei, Taiwan
shengmou@ha.mc.ntu.edu.tw


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Therapeutic Effects of Hyaluronic Acid on Osteoarthritis of the Knee. A Meta-Analysis of Randomized Controlled Trials
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