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The Journal of Bone and Joint Surgery (American) 86:146-148 (2004)
© 2004 The Journal of Bone and Joint Surgery, Inc.

Minocycline-Induced Blue-Green Discoloration of Bone

A Case Report

Patrick E. McCleskey, USAF, MC, Capt.1 and Kamala H. Littleton, MD2

1 Department of Aerospace Medicine, David Grant Medical Center, 60AMDS/SGPF, 101 Bodin Circle, Travis Air Force Base, Fairfield, CA 94535
2 Mercy Medical Center, 301 St. Paul Place, POB Suite 812, Baltimore, MD 21202. E-mail address: khlittleton@mercymed.com

Investigation performed at the Department of Orthopaedic Surgery, David Grant Medical Center, Travis Air Force Base, Fairfield, California

The first 150 words of the full text of this article appear below.


   Introduction
 
The long-term use of minocycline has been associated with skin and tooth hyperpigmentation, but cases of bone discoloration have been reported only rarely1-5. Darkly colored bone that is encountered during a routine arthroplasty presents a dilemma because of the uncertainty regarding its etiology, the structural soundness of the bone, and the ability of the bone to heal. We report the case of an elderly man with a history of long-term minocycline use in whom blue-green discoloration of bone was found during routine total knee arthroplasty. The patient was informed that data concerning this case would be submitted for publication.


   Case Report
 
An eighty-one-year-old man was referred to us with a five-year history of severe, progressive pain in the right knee. His medical history was remarkable for hypertension, benign prostatic hypertrophy, gastroesophageal reflux disease, basal cell and squamous cell carcinomas, and rosacea. His medications included atenolol, felodipine, oxybutynin, rabeprazole, rofecoxib, and minocycline, . . . [Full Text of this Article]


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