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The Journal of Bone and Joint Surgery (American) 85:129-131 (2003)
© 2003 The Journal of Bone and Joint Surgery, Inc.

Long-Term Bactericidal Properties of a Gentamicin-Coated Antimicrobial External Fixation Pin Sleeve

James S. Marotta, PHD, Kevin J. Coupe, MD, Richard Milner, PHD and Kim E. Heseltine

Corresponding author:
James S. Marotta, PhD
Orthopaedic Division, Smith and Nephew, Inc., 1450 Brooks Road,
Memphis, TN 38116. E-mail address: james.marotta@smith-nephew.com

The first 150 words of the full text of this article appear below.

External fixation is a versatile method of fracture treatment. However, pin-track infections remain a major complication. Despite the routine use of antibiotics, pin-track infections occur in 57% to 75% of cases1,2. One factor contributing to the high prevalence of infection is the access that the pin track provides to bacteria and the ability of bacteria to colonize the metal surface of the pin or wire. The OrthoGuard AB antimicrobial sleeve (Smith and Nephew, Memphis, Tennessee) inhibits bacterial colonization on external fixation pins and wires by providing sustained local delivery of gentamicin to the pin or wire site.

In order for local antibiotic delivery to be bactericidal, (1) the antibiotic must be effective against pathogens common to pin-track infections and (2) the sleeve must deliver an effective dose into the pin track in a sustained manner.

The purpose of the present study was to evaluate the results of in vitro . . . [Full Text of this Article]


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