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The Journal of Bone and Joint Surgery (American) 85:82-88 (2003)
© 2003 The Journal of Bone and Joint Surgery, Inc.

Orthopaedic Applications

Clinical Applications of Recombinant Human BMPs: Early Experience and Future Development

Thomas A. Einhorn, MD

Corresponding author: Thomas A. Einhorn, MD
Department of Orthopaedic Surgery, Boston University Medical Center, 720 Harrison Avenue, Suite 808, Boston, MA 02118. E-mail address: thomas.einhorn@bmc.org

The author did not receive grants or outside funding in support of his research or preparation of this manuscript. He received payments or other benefits or a commitment or agreement to provide such benefits from commercial entities (Stryker Biotech and Wyeth Research). In addition, commercial entities (Stryker Biotech and Wyeth Research) paid or directed, or agreed to pay or direct, benefits to a research fund, foundation, educational institution, or other charitable or nonprofit organization with which the author is affiliated or associated.

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In 1965, Marshall R. Urist made the seminal discovery that the extracellular matrix of bone contains a substance that has the capacity to induce new bone formation when implanted into extraskeletal sites in a host 1 . This substance, later named bone morphogenetic protein (BMP), has become the subject of extensive research aimed at developing therapeutic strategies for the restoration and treatment of skeletal conditions resulting from trauma, degenerative disease, or ablative surgery. By 1998, a team of investigators at Genetics Institute (now Wyeth Research, Cambridge, Massachusetts) characterized the molecular clones and activities associated with this protein and derived the amino acid sequence from a highly purified preparation obtained from bovine bone 2 . This led to the isolation and expression of human complementary DNAs (cDNAs), recognized as members of the transforming growth factor-ß supergene family. Over the course of the next fifteen years, investigators elucidated the molecular genetics of BMP biology, . . . [Full Text of this Article]


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