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The Journal of Bone and Joint Surgery (American) 85:8-12 (2003)
© 2003 The Journal of Bone and Joint Surgery, Inc.

Marshall R. Urist Lectures

Osteoporosis and Bisphosphonates*

Gideon A. Rodan, MD, PhD and Alfred A. Reszka, PhD

Corresponding author: Alfred A. Reszka, PhD
Department of Bone Biology and Osteoporosis Research, Merck Research Laboratories, West Point, PA 19486. E-mail address: alfred_reszka@merck.com

The authors did not receive grants or outside funding in support of their research or preparation of this manuscript. They did not receive payments or other benefits or a commitment or agreement to provide such benefits from a commercial entity. No commercial entity paid or directed, or agreed to pay or direct, any benefits to any research fund, foundation, educational institution, or other charitable or nonprofit organization with which the authors are affiliated or associated.

*Marshal R. Urist Lecture

The first 150 words of the full text of this article appear below.

A large number of orthopaedic patients have osteoporosis. They are typically elderly women (usually older than sixty) or older men with back pain and fractures of the hip, spine, wrist, or other bones. Osteoporosis is the primary risk factor for fractures in the elderly, who can be treated to effectively reduce fracture risk. Osteoporosis is defined as a reduction in bone mass and a deterioration in bone microarchitecture resulting in increased bone fragility and fracture risk. It is diagnosed noninvasively by measuring bone density, often with the use of dual-energy x-ray absorptiometry (DXA). This brief review summarizes the pathophysiology and epidemiology of osteoporosis and focuses on bisphosphonates, the most effective therapy available today 1 .

Pathophysiology and Epidemiology of Osteoporosis

To carry out the skeletal functions of calcium homeostasis and mechanical support, microscopic bone units are continuously remodeled, resorbed by osteoclasts, and then rebuilt by osteoblasts. Cancellous bone is remodeled at a rate of ~30%/yr and . . . [Full Text of this Article]


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