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The Journal of Bone and Joint Surgery (American) 85:109-115 (2003)
© 2003 The Journal of Bone and Joint Surgery, Inc.

Orthopaedic Applications

Articular Cartilage Engineering with Autologous Chondrocyte Transplantation

A Review of Recent Developments

Mats Brittberg, MD, PhD, Lars Peterson, MD, PhD, Eva Sjouml;gren-Jansson, MSc, Tommi Tallheden, BSc and Anders Lindahl, MD, PhD

Corresponding author: Mats Brittberg, MD, PhD
Cartilage Research Unit, Department of Orthopaedics, Göteborg University, Kungsbacka Hospital, S-434 80 Kungsbacka, Sweden. E-mail address: mats.brittberg@telia.com

In support of their research or preparation of this manuscript, one or more of the authors received grants or outside funding from the Swedish Medical Research Council, Göteborg University. None of the authors received payments or other benefits or a commitment or agreement to provide such benefits from a commercial entity. No commercial entity paid or directed, or agreed to pay or direct, any benefits to any research fund, foundation, educational institution, or other charitable or nonprofit organization with which the authors are affiliated or associated.

The first 150 words of the full text of this article appear below.

Although several attempts to improve the repair of injured articular cartilage have recently been described 1-6 , articular cartilage resurfacing remains a formidable challenge. Most current cartilage-repair methods depend on an introduction of chondrogenic cells into the defect area. Which cells are best to use and which donor tissue is best for harvesting the cells have yet to be determined. However, since chondrocytes are responsible for the unique features of articular cartilage, it seems rational to use truly committed chondrocytes to repair an articular cartilage defect.

In Gothenburg, Sweden, the experience with biological articular resurfacing dates back to the early 1980s. This research has been focused on the use of autologous articular chondrocytes 7-10 for the repair of focal articular cartilage defects, even though other chondrogenic cells are possible alternatives. The primary goal of the initial in vitro chondrocyte cell culture is to increase the number of cells in order to provide . . . [Full Text of this Article]


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