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The Journal of Bone and Joint Surgery (American) 85:1-2 (2003)
© 2003 The Journal of Bone and Joint Surgery, Inc.

Introductory Comments

Lawrence C. Rosenberg, MD

Deputy Editor for Research, The Journal of Bone and Joint Surgery

The first 20% of the full text of this article appears below.

This supplement to The Journal of Bone and Joint Surgery consists of articles based on presentations delivered at the Fourth International Conference on Bone Morphogenetic Proteins, held in Sacramento, California, in October 2002. Many of these articles, particularly those on the clinical applications of recombinant human bone morphogenetic proteins (rhBMPs), will be of special interest to orthopaedic surgeons. For example, Einhorn 1 summarizes the results of prospective, randomized clinical trials of the use of rhBMPs in the treatment of tibial nonunions and open tibial shaft fractures. On the basis of the results of the tibial nonunion study 2 , the United States Food and Drug Administration has issued a Humanitarian Device Exemption for the use of an OP-1 (rhBMP-7) implant as "an alternative to the patient's own bone (autograft) in recalcitrant long bone nonunions where autograft is unfeasible and alternative treatments have failed." 3

Sandhu and Khan 4 . . . [Full Text of this Article]


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