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The Journal of Bone and Joint Surgery (American) 85:137-141 (2003)
© 2003 The Journal of Bone and Joint Surgery, Inc.

Scientific Article

Cellular Signaling in Developmental Chondrogenesis: N-Cadherin, Wnts, and BMP-2

Rocky S. Tuan, PhD

The first 150 words of the full text of this article appear below.


   Introduction
 
Cartilage formation in the developing vertebrate embryonic limb consists of a highly coordinated and orchestrated series of events involving the commitment, condensation, and chondrogenic differentiation of mesenchymal cells and the production of the cartilaginous matrix 1 . Endochondral ossification ensues upon maturation and hypertrophy of the cartilage, resulting in the formation of the osseous elements of the limb. The recapitulation of this sequence of events during skeletal wound-healing and fracture-healing in postnatal life underscores the importance of understanding the cellular and molecular mechanisms that are responsible for initiating and regulating the early steps of cartilage development.

Embryonic cartilage development has been shown to be under the regulation of a number of biological factors, including members of the transforming growth factor-ß (TGF-ß) superfamily such as the bone morphogenetic proteins (BMPs), fibroblast growth factors (FGFs), and the Wnt family of secreted glycoproteins as well as cell adhesion proteins (e.g., neural cadherin [N-cadherin] and . . . [Full Text of this Article]


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