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The Journal of Bone and Joint Surgery (American) 84:S123-S128 (2002)
© 2002 The Journal of Bone and Joint Surgery, Inc.

Scientific Exhibits

Hip Prosthesis of Antibiotic-Loaded Acrylic Cement for the Treatment of Infections Following Total Hip Arthroplasty

Steven J. Wentworth, BS, Bassam A. Masri, MD, Clive P. Duncan, MD and Carleton B. Southworth, BA, MS

Corresponding author:
Bassam A. Masri, MD
Department of Orthopaedics, Vancouver Hospital and Health Sciences Center, University of British Columbia, Vancouver, British Columbia, Canada, V5Z4E1. E-mail address for B. Masri: masri@interchange.ubc.ca


The authors did not receive grants or outside funding in support of their research or preparation of this manuscript. One or more of the authors received payments or other benefits or a commitment or agreement to provide such benefits from a commercial entity (DePuy). No commercial entity paid or directed, or agreed to pay or direct, any benefits to any research fund, foundation, educational institution, or other charitable or nonprofit organization with which the authors are affiliated or associated.

The first 150 words of the full text of this article appear below.


   Introduction
 
Infection continues to be one of the most feared complications of total hip arthroplasty. Despite many advances over the past three decades, this infrequent complication continues to undermine an otherwise highly predictable and successful procedure. The prosthesis of antibiotic-loaded acrylic cement (PROSTALAC; DePuy, Warsaw, Indiana) is a temporary hip-replacement articulated spacer intended for patients who need a two-stage exchange arthroplasty for the treatment of a confirmed or suspected infection at the site of a total hip replacement. This device has received approval from the United States Food and Drug Administration as a humanitarian use device. (This humanitarian device has been authorized by federal law as a short-term total hip replacement [THR] in patients who need a two-stage procedure to treat a confirmed infection of their THR and where vancomycin and tobramycin are the most appropriate antibiotics for treatment of the infection based on the susceptibility pattern of the infecting microorganism[s]. . . . [Full Text of this Article]


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