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The Journal of Bone and Joint Surgery (American) 83:1396-1402 (2001)
© 2001 The Journal of Bone and Joint Surgery, Inc.

Case Report

Metastatic Mixed Tumor Arising in Bone

A Case Report and Review of the Literature

Richard L. McGough, MD, Li Juan Wang, MD, Douglas R. Gnepp, MD and Richard M. Terek, MD

Investigation performed at Rhode Island Hospital, affiliated with Brown University School of Medicine, Providence, Rhode Island
Richard L. McGough, MD
Li Juan Wang, MD
Douglas R. Gnepp, MD
Departments of Orthopaedics (R.L.McG.) and Pathology (L.J.W. and D.R.G.), Rhode Island Hospital, 593 Eddy Street, Providence, RI 02903

Richard M. Terek, MD
University Orthopedics, Medical Office Center, 2 Dudley Street, Suite 200, Providence, RI 02905. E-mail address: richard_terek@brown.edu

No benefits in any form have been received or will be received from a commercial party related directly or indirectly to the subject of this article. No funds were received in support of this study.


   Introduction
 
Mixed tumors, or pleomorphic adenomas, are the most common benign tumors of the salivary gland1. Minsen2 first described them in 1874 as heterogeneous tumors of the parotid gland containing both mesenchymal and epithelial features3. An entity known as benign metastasizing mixed tumor has also been described4,5. It occurs when a histologically benign mixed tumor metastasizes to other sites, such as soft tissue, the liver, and bone4-7. Rarely, malignant mixed tumors arise in extrasalivary locations, including bone4,8. We know of one case report in which a mixed tumor with malignant characteristics arose in bone and metastasized to the lungs9. We report the first case that we are aware of in which a histologically benign mixed tumor arising in bone metastasized to the lungs. Histologic examination of the metastatic lesion revealed tissue identical to the primary lesion, with no evidence of malignant degeneration.


   Case Report
 
A forty-two-year-old woman . . . [Full Text of this Article]


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