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The Journal of Bone and Joint Surgery (American) 83:S8-18 (2001)
© 2001 The Journal of Bone and Joint Surgery, Inc.

Scientific Article

Radiographic and Histologic Assessment of Calcium Sulfate in Experimental Animal Models and Clinical Use as a Resorbable Bone-Graft Substitute, a Bone-Graft Expander, and a Method for Local Antibiotic Delivery

One Institution’s Experience

Thomas M. Turner, DVM, Robert M. Urban, Steven Gitelis, MD, Ken N. Kuo, MD and Gunnar B.J. Andersson, MD

Thomas M. Turner, DVM
Robert M. Urban
Steven Gitelis, MD
Ken N. Kuo, MD
Gunnar B.J. Andersson, MD
Department of Orthopedic Surgery, Rush-Presbyterian-St. Luke’s Medical Center, 1653 West Congress Parkway, 1471 Jelke, Chicago, IL 60612

In support of their research or preparation of this manuscript, one or more of the authors received grants or outside funding from Wright Medical Technology. In addition, one or more of the authors received payments or other benefits or a commitment or agreement to provide such benefits from a commercial entity (Wright Medical Technology). No commercial entity paid or directed, or agreed to pay or direct, any benefits to any research fund, foundation, educational institution, or other charitable or nonprofit organization with which the authors are affiliated or associated.

The first 150 words of the full text of this article appear below.


   Introduction
 
For more than a decade, the radiographic and histologic appearance of a refined calcium sulfate has been studied in various experimental animal models in our laboratory and in clinical applications. This report summarizes our institution’s experience with calcium sulfate as a synthetic bone graft1, a graft expander (the synergistic combination of calcium sulfate with demineralized bone matrix)2-4, and a method for local delivery of antibiotics5-8. Historically, orthopaedic usage of calcium sulfate was popularized by Peltier. Clinically, we have used calcium sulfate to treat numerous osseous lesions and conditions occurring in the axial and appendicular skeleton, including a variety of benign lesions of bone, osseous defects following implant removal, corrective osteotomy sites, spinal fusion sites, graft sites, fracture defects, and osteomyelitic lesions.

Both our research studies and clinical experience have shown consistent osteoconduction, excellent biocompatibility, and complete resorption of calcium sulfate, which was replaced by newly formed bone . . . [Full Text of this Article]


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