The Journal of Bone and Joint Surgery 83:259 (2001)
© 2001 The Journal of Bone and Joint Surgery, Inc.
The Use of Low-Intensity Ultrasound to Accelerate the Healing of Fractures
Clinton Rubin, PhD,
Mark Bolander, MD,
John P. Ryaby, BS and
Michael Hadjiargyrou, PhD
Clinton Rubin, PhD
Michael Hadjiargyrou, PhD
Department of Biomedical Engineering, State University of New York
at Stony Brook, Stony Brook, NY 11794-2580. E-mail address for C.
Rubin: clinton.rubin@sunysb.edu
Mark Bolander, MD
Department of Orthopedics, Mayo Clinic, 200 First Street S.W., Rochester,
MN 55905
John P. Ryaby, BS
Exogen, Incorporated, 10 Constitution Avenue, Piscataway, NJ 08855
One or more of the authors has received or will receive benefits
for personal or professional use from a commercial party related
directly or indirectly to the subject of this article. No funds
were received in support of this study.
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Introduction
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Double-blind, prospective, placebo-controlled clinical trials
demonstrate that healing times of fresh fractures of the radius
and tibia are reduced by up to 40% with the use of low-intensity
ultrasound.
Animal studies indicate that low-intensity ultrasound exposure
results in stronger and stiffer callus formation and in acceleration
of the endochondral ossification process.
Extensive clinical evidence demonstrates that ultrasound represents
a safe, noninvasive method of accelerating the healing of fresh
fractures of the tibia, the distal aspect of the radius, the scaphoid, and
the metatarsals.
Clinical studies indicate that ultrasound reduces the confounding
effect of smoking and patient age on the fracture-healing process.
Ultrasound requires a brief, twenty-minute, daily at-home treatment
regimen and has no known contraindications.
The effectiveness of low-intensity ultrasound has also been demonstrated
in the clinical treatment of delayed unions and nonunions.
Fracture-healing is a complex biological process that involves
the spatial and temporal orchestration of numerous cell types, . . . [Full Text of this Article]
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