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The Journal of Bone and Joint Surgery (American) 83:S79-S81 (2001)
© 2001 The Journal of Bone and Joint Surgery, Inc.

Introduction - Part 2

The Influence of Delivery Vehicles and Their Properties on the Repair of Segmental Defects and Fractures with Osteogenic Factors

Howard Seeherman, PhD, VMD

The first 150 words of the full text of this article appear below.

Normal fracture-healing involves a number of osteogenic factors that are released from bone and the surrounding soft tissues during the repair process. Osteogenic factors are involved in a number of processes related to bone formation and bone-remodeling, including chemotaxis, proliferation, and differentiation of bone-forming and bone-remodeling cells, blood vessels, nerves, and marrow elements. Local release of physiologic quantities of these osteogenic factors is generally sufficient to elicit fracture repair. Considerable effort has been expended in an attempt to accelerate fracture repair and to increase the assurance of healing by the exogenous application of these osteogenic factors. Similar efforts have been made to bridge critical-sized segmental defects and nonunions with the use of osteogenic factors. Determining the appropriate delivery vehicle for local application of these factors has been one of the major limitations to the success of these therapies. In addition, supraphysiologic doses of osteogenic factors appear to be required to . . . [Full Text of this Article]


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