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The Journal of Bone and Joint Surgery (American) 83:S163-163 (2001)
© 2001 The Journal of Bone and Joint Surgery, Inc.

Commentary

Thoughts on Clinical Trials to Evaluate the Action and Effectiveness of BMPs in Bone Healing

Michael W. Chapman, MD

University of California at Davis, Department of Orthopaedic Surgery, 4860 Y Street, Suite 3800, Sacramento, CA 95817

The author did not receive grants or outside funding in support of his research or preparation of this manuscript. He did not receive payments or other benefits or a commitment or agreement to provide such benefits from a commercial entity. No commercial entity paid or directed, or agreed to pay or direct, any benefits to any research fund, foundation, educational institution, or other charitable or nonprofit organization with which the author is affiliated or associated.

The first 150 words of the full text of this article appear below.

Bone morphogenetic proteins (BMPs) have a number of potential applications in bone healing and in the treatment of other bone disorders. Potential applications include the following:

accelerating normal bone healing

increasing the prevalence of the union of fractures and potentially increasing the strength of the callus formed in initial fracture healing

increasing the effectiveness of autologous or allogeneic bone grafting to improve fracture healing, heal bone defects, or treat nonunions

accelerating the rate of consolidation and increasing the prevalence of union in distraction osteogenesis

replacing autogenous bone graft in treating deficiencies in bone union to eliminate the cost and morbidity of harvesting autologous bone

increasing the rate of consolidation and strength of bone union in reconstructive procedures such as spine arthrodesis and other arthrodeses

inducing bone formation in pathological bone defects

increasing bone mass disorders such as postmenopausal and disuse osteoporosis

In clinical trials of BMPs, investigators thus far have . . . [Full Text of this Article]


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