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The Journal of Bone and Joint Surgery (American) 83:S161-S162 (2001)
© 2001 The Journal of Bone and Joint Surgery, Inc.

Commentary

BMPs: Why Are They Not in Everyday Use?

Joseph M. Lane, MD

The Hospital for Special Surgery, 535 East 70th Street, New York, NY 10021

The author did not receive grants or outside funding in support of his research or preparation of this manuscript. The author received payments or other benefits or a commitment or agreement to provide such benefits from a commercial entity (Genetics Institute, Inc.). No commercial entity paid or directed, or agreed to pay or direct, any benefits to any research fund, foundation, educational institution, or other charitable or nonprofit organization with which the author is affiliated or associated.

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Since the pioneering work of Marshall Urist, who was able to identify a family of proteins that have the property of osteoinduction, investigators in many laboratories have shown that bone morphogenetic proteins (BMPs) will elicit the differentiation of non-committed stem cells along the line leading to the formation of bone. Not only are the BMPs able to stimulate progenitor cells to differentiate and form bone, but in appropriate environments, they can produce cartilage, tendon, or ligament. Recent data suggest that certain BMPs may even lead to the partial repair of nerve and kidney. Recombinant forms of BMPs, particularly BMP2, 4, and 7, have the capability of healing critical-sized bone defects in rodents, dogs, sheep, and primates when combined with a carrier of collagen, guanidine-extracted demineralized bone matrix, hydroxyapatite, or biodegradable polymers. Clinical trials using a highly concentrated human extract of BMP have shown promise for the treatment of established non-unions . . . [Full Text of this Article]


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