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The Journal of Bone and Joint Surgery (American) 83:1871-1876 (2001)
© 2001 The Journal of Bone and Joint Surgery, Inc.

Current Concepts Review

Brain and Bone: Central Regulation of Bone Mass

A New Paradigm in Skeletal Biology

Michael Haberland, MD, Arndt F. Schilling, MD, Johannes M. Rueger, MD and Michael Amling, MD

Investigation performed at the Department of Trauma and Reconstructive Surgery, Hamburg University School of Medicine, Hamburg, Germany

Michael Haberland, MD
Arndt F. Schilling, MD
Johannes M. Rueger, MD
Michael Amling, MD
Department of Trauma and Reconstructive Surgery, Hamburg University School of Medicine, Martinistrasse 52, 20246 Hamburg, Germany. E-mail address for M. Amling: amling@uke.uni-hamburg.de

In support of their research or preparation of this manuscript, one or more of the authors received grants or outside funding from German Research Community (DFG), Grant AM 103/8-1. None of the authors received payments or other benefits or a commitment or agreement to provide such benefits from a commercial entity. No commercial entity paid or directed, or agreed to pay or direct, any benefits to any research fund, foundation, educational institution, or other charitable or nonprofit organization with which the authors are affiliated or associated.


   Introduction
 
Bone-remodeling is the cellular process used by vertebrates to maintain a nearly constant bone mass between the end of puberty and the time of cessation of gonadal function.

Body weight, fertility, and bone formation are regulated, at least in part, by the same hormone, leptin, which exerts its control through hypothalamic pathways.

Bone-remodeling disorders such as osteoporosis are, in part, hypothalamic diseases, and modulation of central signaling pathways can be used to overcome the skeletal consequences of gonadal failure and to potentially restore bone mass.

Bone mass is of critical importance for skeletal integrity and skeletal function. A sufficient bone stock is required for locomotion, for protection of inner organs, as a reservoir of vital ions, and as the scaffold for skeletal repair and osteosynthesis. Bone-remodeling is the physiological process used by vertebrates to maintain a constant bone mass between the end of puberty and the time of cessation of . . . [Full Text of this Article]


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