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The Journal of Bone and Joint Surgery 82:874 (2000)
© 2000 The Journal of Bone and Joint Surgery, Inc.

Evidence-Based Orthopaedics

Botulinum toxin type A improved ankle function in children with cerebral palsy and dynamic equinus foot deformity

L A Koman, J F Mooney, 3rd, B P Smith, F Walker and J M Leon

Source of funding: Allergan, Inc.
For correspondence: Dr. L.A. Koman, Department of Orthopedic Surgery, Wake Forest University, School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1070, USA. E-mail: lakoman@bgsm.edu.

Koman LA, Mooney JF 3d, Smith BP, Walker F, Leon JM, the BOTOX Study Group. Botulinum toxin type A neuromuscular blockade in the treatment of lower extremity spasticity in cerebral palsy: a randomized, double-blind, placebo-controlled trial. J Pediatr Orthop. 2000 Jan-Feb;20:108-15.

Question: In children with cerebral palsy and dynamic equinus foot deformity, is neuromuscular blockade with botulinum toxin type A (BTX) effective and safe for improving ankle function?

Design: Randomized (unclear allocation concealment), double-blind, placebo-controlled trial with 12-week follow-up.

Setting: Clinical centers in the United States, Canada, and Spain.

Patients: 114 children (60% boys) who were 2 to 16 years of age, were hemiplegic . . . [Full Text of this Article]


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