The Journal of Bone and Joint Surgery 82:873 (2000)
© 2000 The Journal of Bone and Joint Surgery, Inc.
Evidence-Based Orthopaedics |
Commentary
Peter C. Amadio, M.D.
Department of Orthopedic Surgery, Mayo Clinic, Rochester, Minnesota
Vitamin C has been the subject of thousands of reports since
Linus Pauling first suggested that it had a therapeutic effect in
reducing the severity of the common cold1 and,
later, in the treatment of cancer and atherosclerosis. Subsequently,
larger population-based studies have nearly uniformly discounted
these effects as resulting from various forms of research bias,
often in the nature of the study design2-4.
This prospective, randomized, blinded study reports an impressive
effect from a daily dose of 500 mg of vitamin C on the . . . [Full Text of this Article]

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