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The Journal of Bone and Joint Surgery 82:873 (2000)
© 2000 The Journal of Bone and Joint Surgery, Inc.


Evidence-Based Orthopaedics

Commentary

Peter C. Amadio, M.D.

Department of Orthopedic Surgery, Mayo Clinic, Rochester, Minnesota

Vitamin C has been the subject of thousands of reports since Linus Pauling first suggested that it had a therapeutic effect in reducing the severity of the common cold1 and, later, in the treatment of cancer and atherosclerosis. Subsequently, larger population-based studies have nearly uniformly discounted these effects as resulting from various forms of research bias, often in the nature of the study design2-4. This prospective, randomized, blinded study reports an impressive effect from a daily dose of 500 mg of vitamin C on the . . . [Full Text of this Article]


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