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The Journal of Bone and Joint Surgery 82:752 (2000)
© 2000 The Journal of Bone and Joint Surgery, Inc.

Letters to The Editor

Role of Heparin in Compartment Syndrome

James M. Hynson, M.D., John A. McLaughlin, M.D., Melyssa M. Paulson, M.D. and Ronald E. Rosenthal, M.D.

To The Editor:

The case report entitled "Delayed Onset of Anterior Tibial Compartment Syndrome in a Patient Receiving Low-Molecular-Weight Heparin. A Case Report" (80-A: 1789-1790, Dec. 1998), by McLaughlin et al., should serve as another reminder that pharmacological prophylaxis against venous thromboembolism may be associated with serious risks. Hemorrhagic risks are particularly important to consider as the envelope of anticoagulation is pushed further by the enthusiasm with which low-molecular-weight heparins have been embraced in the medical and surgical community. The introduction of enoxaparin in the United States at postoperative dosage strengths in excess of those previously used in Europe has resulted in the emergence of one of the most important issues now facing anesthesiologists and orthopaedic surgeons in their routine management of patients who have a joint replacement procedure - that is, an increased, and . . . [Full Text of this Article]


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