The Journal of Bone and Joint Surgery 82:455 (2000)
© 2000 The Journal of Bone and Joint Surgery, Inc.
Editorial. A Potential Concern in Total Joint Arthroplasty: Systemic Dissemination of Wear Debris
Charles R. Clark, M.D., Deputy Editor for Adult Reconstruction
This issue of The Journal contains an important
article by Urban et al., which discusses the dissemination of wear
particles to the liver, spleen, and abdominal lymph nodes of patients
who have had a total hip or knee replacement and focuses on the
systemic effects rather than the local effects of a total joint
arthroplasty12.
In a 1993 issue of The Journal, an editorial
that I coauthored proclaimed that the problem in total joint arthroplasty
was aseptic loosening5. Indeed,
osteolysis and aseptic loosening are the most frequently recognized
complications of total joint arthroplasty13.
Much is known about the mechanical production of wear debris stimulating
a biological response leading to osteolysis and, in many cases,
to loosening of the implant.
In situ degradation of implants commonly occurs.
The most prevalent form of such degradation is wear, but there also
can be corrosion of the metallic components of the . . . [Full Text of this Article]

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