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The Journal of Bone and Joint Surgery 81:1305-11 (1999)
© 1999 The Journal of Bone and Joint Surgery, Inc.

Mycobacterium bovis Osteomyelitis as a Complication of Bacille Calmette-Guérin (BCG) Vaccination: Rapid Diagnosis with Use of DNA Sequencing Analysis. A Case Report*

CHII-JENG LIN, M.D., PH.D.{dagger}, WANG-SHENG YANG, M.D.{ddagger}, JING-JOU YAN, M.D.{dagger} and CHING-CHUAN LIU, M.D.{dagger}, TAINAN, TAIWAN

Investigation performed at National Cheng Kung University Medical College, Tainan


   Introduction
 
Vaccination with bacille Calmette-Guérin (BCG) has been used for the prevention of tuberculosis in many areas of the world. It is estimated that more than three billion people worldwide have been vaccinated with live BCG since 19459. In almost all children, inoculation with BCG is harmless. However, it must be understood that BCG, like other vaccines, such as that for poliomyelitis and even that for measles, mumps, and rubella, occasionally produces adverse reactions5,11,21-23. Despite these rare complications, BCG has proved to be effective for preventing miliary tuberculosis and tubercular meningitis in many developing countries. Disseminated complications were observed in association with approximately one per million vaccinations, and severe local reactions occurred in approximately 2 percent of individuals who were vaccinated11,22,23. BCG osteomyelitis has been reported often in Europe but relatively rarely elsewhere1-3,6,7,13,25; however, it may not be as rare as it seems. It is possible that . . . [Full Text of this Article]


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