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The Journal of Bone and Joint Surgery 81:703-7 (1999)
© 1999 The Journal of Bone and Joint Surgery, Inc.

Recurrent Giant-Cell Tumor Presenting as a Soft-Tissue Mass. A Report of Four Cases*

FRANCIS YOUNG-IN LEE, M.D.{dagger}, MARK MONTGOMERY, M.D.{dagger}, ERIC J. HAZAN, M.D.{dagger}, SUZANNE B. KEEL, M.D.{dagger}, HENRY J. MANKIN, M.D.{dagger} and SUSAN KATTAPURAM, M.D.{dagger}, BOSTON, MASSACHUSETTS

Investigation performed at Massachusetts General Hospital and Harvard Medical School, Boston


   Introduction
 
Giant-cell tumor of bone is a benign, locally invasive tumor that has been associated with a rate of local recurrence of 27 percent (forty-one of 151) after intralesional excision and 8 percent (ten of 122) after marginal excision1. The high rate of local recurrence and the occasional development of pulmonary metastasis are manifestations of the locally invasive nature of the tumor4-6,8,9,11,12.

A peripheral rim of ossification has been described as an almost pathognomonic sign of a soft-tissue recurrence2,3,11. However, a soft-tissue recurrence can be difficult to detect, especially when the recurrent lesion is asymptomatic and is not associated with the characteristic ossification.

We report on four patients who had an isolated soft-tissue recurrence of a giant-cell tumor of bone. Although a radiodense peripheral rim of ossification is thought to be pathognomonic of a soft-tissue recurrence of giant-cell tumor, this finding was not apparent on the plain radiographs . . . [Full Text of this Article]


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M. D. Murphey, G. C. Nomikos, D. J. Flemming, F. H. Gannon, H. T. Temple, and M. J. Kransdorf
Imaging of Giant Cell Tumor and Giant Cell Reparative Granuloma of Bone: Radiologic-Pathologic Correlation
RadioGraphics, September 1, 2001; 21(5): 1283 - 1309.
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