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The Journal of Bone and Joint Surgery 81:599-602 (1999)
© 1999 The Journal of Bone and Joint Surgery, Inc.

Editorial

New Horizons in Orthopaedic Research: Elucidation of Cellular Signal Transduction Pathways

KENNETH A ROEBUCK, Ph.D., JOSHUA J. JACOBS, M.D. and TIBOR T. GLANT, M.D., Ph.D.

The report by Nakashima et al.6 in this issue of The Journal and the one by Blaine et al.3 in the October 1997 issue dealt with signal transduction mechanisms in macrophages stimulated by orthopaedic biomaterials. Although these pioneering studies represent initial findings and focus on only a narrow range of possible signaling events, they open new vistas within clinically oriented orthopaedic research. The ultimate aim of this new line of research is to delineate the fundamental cellular mechanisms of periprosthetic osteolysis induced by particulate wear debris and to establish strategies for the development of therapeutic agents to prevent, reverse, or retard this adverse outcome of joint replacement procedures. Furthermore, the study of cellular signal transduction pathways can be applied to numerous areas of orthopaedic research, including the growth and development of cartilage and bone, the pathogenesis of osteoarthritis, fracture-healing, and tumor growth, to name but a few.

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