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The Journal of Bone and Joint Surgery 81:564-70 (1999)
© 1999 The Journal of Bone and Joint Surgery, Inc.

Osteosarcoma Arising from Heterotopic Ossification After an Electrical Burn. A Case Report*

ALBERT J. ABOULAFIA, M.D.{dagger}, FLEMING BROOKS, M.D.{dagger}, JOANNE PIRATZKY, M.D.{dagger} and SHARON WEISS, M.D.{dagger}, ATLANTA, GEORGIA

Investigation performed at the Departments of Orthopaedic Surgery and Pathology, Emory University School of Medicine, Atlanta


   Introduction
 
Extraskeletal bone formation (heterotopic ossification) may originate in tendons, fasciae, periosteum, subcutaneous fat, or organs such as the kidney or breast22. It is histologically similar to myositis ossificans, which refers more specifically to the formation of bone in muscle tissue. Because of the histological and clinical similarities between heterotopic ossification and osteosarcoma, the conditions can be easily misdiagnosed.

Heterotopic ossification usually develops after a single traumatic injury or a series of minor injuries and is considered to be a benign, self-limiting condition. Thermal injury is one of the least common causes of extraskeletal bone formation. The reported prevalence of heterotopic ossification following thermal injury has ranged from less than 1 to 23 percent6,13,20,25. Boyd et al. retrospectively reviewed the cases of approximately 1000 patients who had been seen during a twenty-five-year period for the treatment of a burn and identified six patients (less than 1 percent) who had . . . [Full Text of this Article]


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