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The Journal of Bone and Joint Surgery 81:558-63 (1999)
© 1999 The Journal of Bone and Joint Surgery, Inc.

Histological and Molecular Evidence of Synovial Sarcoma of Bone. A Case Report*

HIROAKI HIRAGA, M.D.{dagger}, TAKAYUKI NOJIMA, M.D.{ddagger}, KAZUO ISU, M.D.{dagger}, KATSUSHIGE YAMASHIRO, M.D.{dagger}, SHINYA YAMAWAKI, M.D.{dagger} and KAZUO NAGASHIMA, M.D.§, SAPPORO, JAPAN

Investigation performed at the Department of Clinical Research, Sapporo National Hospital, Sapporo


   Introduction
 
Synovial sarcoma is a clinically and morphologically well defined soft-tissue tumor that occurs predominantly in the extremities of adolescents and young adults. It tends to arise in the vicinity of large joints, especially the knee8. This tumor was designated synovial sarcoma because of its anatomical location and its histological resemblance to normal synovial tissue. However, we do not believe that there is any convincing evidence that synovial sarcoma always originates from synovial tissue. It is possible that the lesion sometimes arises from primitive mesenchymal cells rather than from preformed synovial cells; therefore, the development of synovial sarcoma is no longer thought to require the presence of preexisting synovial tissue. To the best of our knowledge, there have been no reports of synovial sarcoma arising in bone.

The reciprocal translocation t(X;18)(p11.2;q11.2) was noted in all twenty-two reported cases of synovial sarcoma that have been studied cytogenetically5,18. This translocation is . . . [Full Text of this Article]


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