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The Journal of Bone and Joint Surgery 80:1349-1354 (1998)
© 1998 The Journal of Bone and Joint Surgery, Inc.

Angiosarcoma of the Hand Associated with Chronic Exposure to Polyvinyl Chloride Pipes and Cement. A Case Report*

DAVID G. MOHLER, M.D.{dagger}, WILLIAM W. CHEN, M.S.{ddagger} and HEIDI BLOOM, M.D.{dagger}, STANFORD, CALIFORNIA

Investigation performed at Stanford University Medical Center, Stanford


   Introduction
 
Angiosarcoma of the liver has been reported to be causally related to chronic exposure to polyvinyl chloride7,14,15,25. Skin contact with products that contain polyvinyl chloride is known to cause a spectrum of vascular dysplasias8,21.

We report the case of a patient who had angiosarcoma of the hand after having been exposed to polyvinyl chloride over a period of eleven years. The patient had lesions involving the nail-folds of three digits (the thumb and the long and ring fingers) as well as several soft-tissue masses in the palm. He also had metastases to the lungs. The treatment included amputation through the distal third of the forearm followed by chemotherapy. The metastatic lesions in the lungs were excised. Six years after treatment, the patient was alive with evidence of recurrent disease.

We believe that angiosarcoma of the hand can result from chronic skin contact with pipes and cement containing polyvinyl . . . [Full Text of this Article]


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