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The Journal of Bone and Joint Surgery 80:604-6 (1998)
© 1998 The Journal of Bone and Joint Surgery, Inc.

Correspondence

Correspondence

D. M. Hunt, F.R.C.S., Z. Holmes, Ph.D., W. Pickering, F.I.B.M.S., H. Cohen, M.D., F.R.C.P., F.R.C.Path., C. J. Glueck, M.D., Richard Freiberg, M.D., Alvin Crawford, M.D., Dennis Roy, M.D., Helen Glueck, M.D. and Davis Stroop, M.S.

TO THE EDITOR:

The etiology of Legg-Perthes disease is poorly understood, but recent reports have suggested a strong association with heritable thrombophilic defects. Glueck et al., in their study "Association of Antithrombotic Factor Deficiencies and Hypofibrinolysis with Legg-Perthes Disease" (78-A: 3–13, Jan. 1996), reported that 59 per cent (twenty-six) of forty-four children who had Legg-Perthes disease had a thrombophilic defect: nineteen (43 per cent) had protein-C deficiency, four (9 per cent) had protein-S deficiency, and three (7 per cent) had hypofibrinolysis. As part of an ongoing, unpublished study, we screened twelve white individuals who had Legg-Perthes disease for heritable thrombophilic defects. The ten male and two female patients had a median age of eleven years (range, six to forty-three years). None of the individuals had a personal or family history of thromboembolism.

We performed several investigations: coagulation screening (prothrombin time, activated partial thromboplastin time, and thrombin time), Clauss fibrinogen11, . . . [Full Text of this Article]


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