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The Journal of Bone and Joint Surgery 80:1791-4 (1998)
© 1998 The Journal of Bone and Joint Surgery, Inc.

Late Foreign-Body Reaction to an Intraosseous Bioabsorbable Polylactic Acid Screw. A Case Report*

OLE M. BÖSTMAN, M.D.{dagger} and HARRI K. PIHLAJAMÄKI, M.D.{dagger}, HELSINKI, FINLAND

Investigation performed at the Department of Orthopaedic and Trauma Surgery, Helsinki University Hospital, Helsinki


   Introduction
 
Local inflammatory and osteolytic foreign-body reactions to bioabsorbable implants made of polyglycolic acid have been well documented in the literature4,5,8,12. Rapid degradation of the polyglycolic acid polymer causes these adverse reactions to occur within two to four months after implantation, when the disintegration of the polymer has reached its final phase6,19.

Polylactic acid is another synthetic biodegradable polymer used in fracture-fixation implants. In contrast to polyglycolic acid, the degradation time of the stereo-isomeric form of polylactic acid that is used most commonly, poly-L-lactic acid, is several years. Consequently, the possible foreign-body reactions to devices made of poly-L-lactic acid can be expected to emerge much later than the reactions to devices made of polyglycolic acid. Because implants made of poly-L-lactic acid have been used clinically on a widespread basis for less than ten years, knowledge of the long-term biocompatibility of this polymer in human tissues is limited. We report . . . [Full Text of this Article]


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