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The Journal of Bone and Joint Surgery 79:959-60 (1997)
© 1997 The Journal of Bone and Joint Surgery, Inc.

Editorial

Editorial - Human Experimentation

Thomas A. Einhorn, M.D., Albert H. Burstein, Ph.D. and Henry R. Cowell, M.D., Ph.D.

At the end of every developmental process in which the intent is to provide a new therapy or to understand a clinical condition better, there is a need to perform experiments on patients. Human experimentation is a necessary part of orthopaedic research, and orthopaedic investigators must recognize that the treatment of patients in clinical trials is neither simple nor intuitive. Clinical research requires the understanding and practice of ethical principles and methods of conduct that have been developed and refined over the past fifty years. These principles govern not only the scientific research process but also the ethics of clinical investigation.

On this, the fiftieth anniversary of the Doctors Trial at Nuremberg, we have an opportunity to reflect on the power of clinical research and the current issues confronting human experimentation. The tenuous nature of a concept such as voluntary consent, the intensity of the profit motive in the health-care . . . [Full Text of this Article]


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