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The Journal of Bone and Joint Surgery 79:633 (1997)
© 1997 The Journal of Bone and Joint Surgery, Inc.

Correspondence

Correspondence

K. Klaue, M.D., Thomas R. Hunt, M.D., John R. Schwappach, M.D. and H. Clarke Anderson, M.D.

TO THE EDITOR:

I read "Healing of a Segmental Defect in the Rat Femur with Use of an Extract from a Cultured Human Osteosarcoma Cell-Line (Saos-2). A Preliminary Report" (78-A: 41–48, Jan. 1996), by Hunt et al., with great interest. Although the authors claimed that this was a preliminary report, I was surprised at the setup of the experiment. We all know the tiny dimensions of a rat femur and the difficulty of creating a reasonably comparable defect in the middle of its diaphysis. I was surprised, however, that the defect was made with a rotating drill-burr, which literally pulverizes the bone while creating an unavoidable heat necrosis. I thank the authors for mentioning this shortcoming in their results. A more reliable and precise manner with . . . [Full Text of this Article]


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