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The Journal of Bone and Joint Surgery 79:318 (1997)
© 1997 The Journal of Bone and Joint Surgery, Inc.

Book Review

BONE MORPHOGENETIC PROTEINS: BIOLOGY, BIOCHEMISTRY AND RECONSTRUCTIVE SURGERY. T. Sam Lindholm. Austin, Texas, R. G. Landes Company and Academic Press, 1996. $69.95, 311 pp.

Thomas A. Einhorn, M.D.

The concept that there is a substance in bone that can induce new-bone formation has been discussed for many years. However, the credit for the discovery of bone morphogenetic protein goes to Marshall R. Urist, who, in 1965, demonstrated the formation of bone by a process that he called autoinduction. With the subsequent identification of a family of molecules known as the bone morphogenetic proteins, clinicians and scientists from all fields of skeletal biology have gravitated to this area of investigation. The reason for this is obvious: if it is possible to develop a material that can be stored in an operating room and then implanted, injected, or otherwise introduced into a patient, the ability to enhance fracture-healing, skeletal reconstruction, and limb salvage after severe trauma could be revolutionized. Consequently, a book that effectively presents the results of thirty years of research on this topic, organizes them, and puts them . . . [Full Text of this Article]


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