This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Letters to the Editor: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when Letters to the Editor are posted
Right arrow Alert me if a correction is posted
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrowReprints and Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by SAKKERS, R. J. B.
Right arrow Articles by HOGENDOORN, P. C. W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by SAKKERS, R. J. B.
Right arrow Articles by HOGENDOORN, P. C. W.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Technorati  
What's this?
The Journal of Bone and Joint Surgery 79:259-62 (1997)
© 1997 The Journal of Bone and Joint Surgery, Inc.

Late Malignant Transformation of a Benign Giant-Cell Tumor of Bone. A Case Report*

R. J. B. SAKKERS, M.D.{dagger}, R. O. VAN DER HEUL, M.D., PH.D.{dagger}, H. M. KROON, M.D., PH.D.{dagger}, A. H. M. TAMINIAU, M.D., PH.D.{dagger} and P. C. W. HOGENDOORN, M.D., PH.D.{dagger}, LEIDEN, THE NETHERLANDS

Investigation performed at Leiden University, Leiden


   Introduction
 
Malignant giant-cell tumors of bone are very rare. These tumors usually present as de novo lesions or, several years after treatment with curettage combined with radiation therapy, as malignant transformation of a benign giant-cell tumor. However, malignant transformation without adjuvant radiation therapy has also been reported1,2,5,8-12,14,16.

We present a well documented case of late progression of a giant-cell tumor of bone to a malignant fibrous histiocytoma.


   Case Report
 
In September 1991, a forty-five-year-old man was seen because of pain on the medial side of the left knee, especially at night. Almost twenty years earlier, in March 1972, a benign osteolytic lesion, which had been radiographically and histologically consistent with a low-grade giant-cell tumor of bone (Figs. 1 and 2), had been removed with curettage from the medial portion of the epiphysis and metaphysis of the proximal aspect of the left tibia. The defect had been filled with bone taken . . . [Full Text of this Article]


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 RadioGraphicsHome page
M. D. Murphey, G. C. Nomikos, D. J. Flemming, F. H. Gannon, H. T. Temple, and M. J. Kransdorf
Imaging of Giant Cell Tumor and Giant Cell Reparative Granuloma of Bone: Radiologic-Pathologic Correlation
RadioGraphics, September 1, 2001; 21(5): 1283 - 1309.
[Abstract] [Full Text] [PDF]