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Instructional Course Lectures, The American Academy of Orthopaedic Surgeons - Growth Factors as Therapeutic Agents*

STEPHEN B. TRIPPEL, M.D., RICHARD D. COUTTS, M.D., THOMAS A. EINHORN, M.D., GREGORY R. MUNDY, M.D. and RON G. ROSENFELD, M.D., BOSTON, MASSACHUSETTS

An Instructional Course Lecture, The American Academy of Orthopaedic Surgeons

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	Introduction

 
Many of the diseases treated by orthopaedic surgeons reflect a failure of the function of specific populations of cells. Skeletal deformities often stem directly or indirectly from the abnormal function of the cells of the growth plate and preosseous cartilage. Impaired healing after an injury is a failure of resident and immigrant cells to restore the tissue at the site of injury. Degenerative osteoarthrosis results from a diminished ability of the cells to balance the repair and degradation of articular cartilage. Osteoporosis is a failure of bone cells to maintain normal bone mass and architecture. Thus, an understanding of the regulation of cell behavior may provide important insight into the cause of orthopaedic diseases, and the ability to control cell behavior would be a powerful tool in the treatment of these diseases. Recent advances in cell and molecular biology have brought us to the point that manipulation of cell behavior . . . [Full Text of this Article]

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