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The Journal of Bone and Joint Surgery 78:1082-7 (1996)
© 1996 The Journal of Bone and Joint Surgery, Inc.

Long-Term Survival of Chondrocytes in an Osteochondral Articular Cartilage Allograft. A Case Report*

F. RICHARD CONVERY, M.D.{dagger}, WAYNE H. AKESON, M.D.{dagger}, DAVID AMIEL, PH.D.{dagger}, MARVIN H. MEYERS, M.D.{dagger} and ANNA MONOSOV, PH.D.{dagger}, SAN DIEGO, CALIFORNIA

Investigation performed at the Department of Orthopaedics and Rehabilitation, University of California, San Diego, San Diego


   Introduction
 
Repair of a localized defect in the articular cartilage with a fresh osteochondral shell allograft is an alternative in a young adult for whom non-operative treatment has failed and prosthetic arthroplasty or arthrodesis of the affected joint is not appropriate. At our institution, the lesions most commonly treated with this technique are traumatic osteochondral defects.

Osteochondral allografts have not gained widespread acceptance, as the good results reported with their use have been based on small series with short-term follow-up from only a few centers2,6,9,12,17. This may be related to the lack of a sophisticated system for procuring donors, the lack of proved storage technology, the fear of transmitted disease, and uncertainty regarding a possible immune response to the allograft14,15. In addition, some tissue banks are reluctant to accept the liability for the dissemination of fresh tissue for a procedure that is not widely used. Yet another factor is . . . [Full Text of this Article]


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