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The Journal of Bone and Joint Surgery 78:767-71 (1996)
© 1996 The Journal of Bone and Joint Surgery, Inc.

Adult-Onset Mitochondrial Myopathy Coexistent with Lumbar Disc Disease. A Case Report*

ROBERT E. CASHMAN, M.D.{dagger}, G. DAVID CASPER, M.D.{ddagger} and ROGER A. BRUMBACK, M.D.{dagger}, OKLAHOMA CITY, OKLAHOMA

Investigation performed at the Department of Pathology, University of Oklahoma Health Sciences Center, and Laboratory Service, Veterans Affairs Medical Center, and Southwest Medical Center, Oklahoma City


   Introduction
 
Mitochondrial diseases are a heterogeneous group of disorders. Abnormal mitochondria may be seen to have altered histological characteristics with the use of light microscopy or at the ultrastructural level, abnormal DNA sequences, alterations in the levels and function of enzymes, or a combination of these abnormalities12,17.

In mitochondrial myopathies, symptoms often are limited to muscle; patients usually have slowly progressive weakness and, frequently, ophthalmoplegia. Weakness generally begins between birth and the age of ten months and is transiently exacerbated by exercise16. The weakness usually is in the proximal portion of the limb but can be in the distal area11. Occasionally, weakness does not appear until adulthood1,2,5,8-10,13,18,19,23.

We report on a patient who had lumbar disc disease and previously undiagnosed mitochondrial myopathy, resulting in long-standing weakness of the muscles of the lower extremities and radicular pain. A decompressive procedure was done for a bulging disc at the . . . [Full Text of this Article]


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