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The Journal of Bone and Joint Surgery 78:472-3 (1996)
© 1996 The Journal of Bone and Joint Surgery, Inc.

Correspondence

Correspondence

Gerhart Waertel, M.D., Clive P. Duncan, M.D., F.R.C.S.(C) and Bassam A. Masri, M.D., F.R.C.S.(C)

TO THE EDITOR:

The article "The Role of Antibiotic-Loaded Cement in the Treatment of an Infection after a Hip Replacement" (76-A: 1742–1751, Nov. 1994), by Duncan and Masri, presented the history and basic science of antibiotic-loaded bone cement in a comprehensive way. The authors should be commended for describing antibiotic-loaded bone cement as an efficacious and viable option in the treatment of infection after hip arthroplasty.

In describing the mechanisms of elution of antibiotic-loaded bone cement, the authors said that "the release of antibiotics occurs only from the surface, from voids and cracks in the bone cement" and cited the study by Baker and Greenham1 to support this observation. The conclusion that "bone cement with greater porosity would be expected to allow more antibiotic release than one with less porosity" was attributed to Baker and Greenham. Given this, Duncan and Masri observed that "it is not surprising, then, that Palacos . . . [Full Text of this Article]


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