The Journal of Bone and Joint Surgery 78:141-9 (1996)
© 1996 The Journal of Bone and Joint Surgery, Inc.
Instructional Course Lecture |
Instructional Course Lectures, The American Academy of Orthopaedic Surgeons - Chondrosarcoma: a Review*
DEMPSEY S. SPRINGFIELD, M.D. ,
MARK C. GEBHARDT, M.D. , BOSTON, MASSACHUSETTS and
MICHAEL H. MCGUIRE, M.D. , OMAHA, NEBRASKA
An Instructional Course Lecture, The American Academy of Orthopaedic Surgeons
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Introduction
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Chondrosarcoma is a malignant tumor of cartilage-producing cells35. It is subdivided in a variety of ways, including by histological grade, by whether it is primary or secondary, and by whether it is peripheral or central; among these, the single most prognostic sub-classification is the histological grade. In addition, there are a few specific histological subtypes of chondrosarcoma: clear-cell, mesenchymal, base of the skull, and soft-parts chondrosarcoma.
Chondrosarcoma is most often separated into three histological grades: low (grade 1), medium (grade 2), and high (grade 3). The higher the grade, the more likely it is that the tumor will metastasize. Grading is based on the tumor's histological appearance, with tumors that most resemble normal cartilage being low-grade (grade 1) and having the least risk of metastasizing, and those that have the most abnormal-appearing cartilage being high-grade (grade 3) and having a higher risk of metastasizing (Figs. 1 and 2. . . [Full Text of this Article]

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